Tšireletseho ea Tšebeliso ea Meriana e Kopantsoeng ea Aluminium ka har'a Packaging ea Tekanyo e Tiileng.
Botšepehi ba sephutheloana sa litekanyetso tse tiileng bo itšetlehile haholo ka ts'ebetso ea Aluminium Barrier Foil, e sebetsang e le mokhoa oa mantlha oa ts'ireletso khahlanong le ho senyeha ha tikoloho bakeng sa lisebelisoa tse hlokolosi tsa Active Pharmaceutical (Apis). Tlhahlobo ena e fana ka lintlha tsa litlhoko tsa sebopeho le ho lekanya boleng ba lithibelo tse phahameng tsa masela a aluminium a kopantsoeng khahlano le litšokelo tsa bohlokoa tsa ho kenella ha mongobo le oksijene..
1. Karolo ea Bohlokoa ea Lisebelisoa tsa Thibelo
Ho boloka botsitso ba lik'hemik'hale le katleho ea kalafo ea mefuta ea litekanyetso tse tiileng tsa molomo ke ntho e ka sehloohong tlhahisong ea meriana..
Hangata li-API li kotsing ea ho senyeha ha maemo, ho akarelletsa le hydrolysis (e tsamaisoang ke mongobo) le oxidation (e tsamaisoang ke oksijene).
Maikutlo ana a hloka lisebelisoa tsa ho paka tse fanang ka ho se khonehe ho hang, tlhokahalo e finyelloang ka mokhoa o ikhethileng ke metsoako ea aluminium.
2. Moralo oa Sebopeho sa Mehala e Kopanetsoeng
Li-foil tse entsoeng ka metsoako ea meriana ke li-laminate tse ngata tse rarahaneng tse entsoeng ho kopanya ts'ebetso e feletseng ea mokoallo oa tšepe le thepa e hlokahalang ea mechine le ea ho tiisa ea li-polymers..
2.1 The Impermeable Core
Motheo oa motsoako ke lera la aluminium, hangata ho tloha 20 $\mu$m ho 50 $\mu$m ka botenya.
Aluminium e teteaneng, thipa e se nang porous metallic ka 'mele e thibelang tsela ea limolek'hule tsa khase le mouoane oa metsi.
Lera lena la tšepe ke karolo ea mantlha e ikarabellang bakeng sa maemo a holimoAluminium Barrier Foiltshebetso.
2.2 Lisebelisoa tsa Polymer tse sebetsang
Mokotla oa aluminium o laminated pakeng tsa likarolo tsa polymeric, se seng le se seng se sebeletsa morero o itseng.
Lera le kantle (E.g., OPA kapa PET) e fana ka matla a mochine le ho hanyetsa abrasion nakong ea ho tšoara.
Lera le ka hare, hangata ke lacquer ea tiiso ea mocheso (HSL) kapa polymer joalo ka PVC, e tiisa hore ho na le matla, tiiso ea mocheso o tlase ho web base ea blister.
3. Ts'ebetso ea Thibelo ea Oksijene (OVP)
Ho etsa lintho ka mokhoa o oxidative ho ka fokolisa ka potlako le ho hlahisa litšila tse sa batleheng.
Sekhahla sa phepelo ea oksijene (ORT), e lekantsoe ho $ mongolo{CC}/(\Mongolo{m}^ 2 cdot mongolo{Letsatsi})$, ke metric e tloaelehileng bakeng sa ovp.
E sa hloekangAluminium Barrier Foile bonts'a ott ott e ka bang zero, hangata e oela ka tlase ho meeli ea ho lemoha e sebelisang lisebelisoa tsa maemo a tloaelehileng (E.g., Lisebelisoa tsa Mokotla).
Kotsi e ka sehloohong ea OVP ke boteng ba li-cmpholes kapa mapetso a micro, e ka hlahisoang nakong ea metsamao kapa metsamao ea morao-rao.
Tafole 1: Litefiso tsa phetiso ea oksijene tsa oksijene (ORT) ea lisebelisoa tsa ho paka
| Mofuta oa thepa | Botenya ($\mu$m) | Maemo a Teko | ORT ($\Mongolo{CC}/(\Mongolo{m}^ 2 cdot mongolo{Letsatsi})$) | Barrier Classification |
| PVC e tloaelehileng | 250 | $23^sedikadikwemongolo{C}$, 0% Rh | 10 - 15 | Tlase |
| PVDC e koahetsoeng ka PVC | 250 | $23^sedikadikwemongolo{C}$, 0% Rh | 0.1 - 1.0 | Bohareng |
| Motsoako oa Aluminium Foil | 25 (Al layer) | $23^sedikadikwemongolo{C}$, 0% Rh | $< 0.005$ | E kgabane |
| Cold Foromo Foil (Alu-Alu) | 45 (Al layer) | $23^sedikadikwemongolo{C}$, 0% Rh | $< 0.001$ | Phahameng |
4. Ts'ebetso ea Thibelo ea Mongobo (MVP)
Sekhahla sa mongobo sa mongobo (Wvtr), e lekantsoe ho $ mongolo{g}/(\Mongolo{m}^ 2 cdot mongolo{Letsatsi})$, hangata ke parameter ea bohlokoa ka ho fetisisa bakeng sa botsitso ba lithethefatsi.
Lera la aluminium le netefatsa boleng bo tlase haholo ba WVTR, Ho EtsaAluminium Barrier Foilea bohlokoa bakeng sa hygroscopic APIs.
4.1 Sistimi ea Alu-Alu
Bakeng sa lithethefatsi tse thibelang mongobo haholo (E.g., Sehlopha sa I API), Alu-Alu blister system e fana ka tšireletso e phahameng.
Sistimi ena e sebelisa foil ea aluminite aluminite bakeng sa litlolo tsa ka bobeli le marang-rang a motheo (Cold Foromo Foil, CFF).
Ts'ebetso ea CFF e hloka taolo e nepahetseng ho thibela li-bractis tse halikiloeng ka har'a khatello ea kelelloAluminium Barrier FoilNakong ea sebopeho sa cavity.
Tafole 2: WVTRT e le molemong oa ho etsa liforomo tse tiileng
| Sehlopha sa Apiti sa Api | Ho hlokahala wvtr ($\Mongolo{g}/(\Mongolo{m}^ 2 cdot mongolo{Letsatsi})$) | Tharollo e tloaelehileng ea ho paka | Libaka tsa Tlhaho ea Sake Mechanism |
| Sehlopha I (Ho tsotella haholo) | $< 0.05$ | Cold Foromo Foil (Alu-Alu) | Haufi-Zero Ho nepahala ha AL |
| Sehlopha II (Ka mokhoa o hlakileng) | $0.05 - 0.5$ | Pvdc / pvc blister ea aluminium | Pvdc coating le tiiso ea aluminium |
| Sehlopha sa III (E se nang kelello) | $> 0.5$ | PVC / Aluminium Blister e tloaelehileng | Aluminium Lidding Seal |
5. Tiisetso ea Boleng le Teko ea Botšepehi
Ho netefatsa ts'ebetso e tsitsitseng ea lithibelo, taolo e tiileng ea boleng ke tlamo nakong eohle ea ho paka.
Teko ea permeation (OTR le WVTR) e netefatsa dibopeho tsa kahare tsa foleteAluminium Barrier FoilLintho tse bonahalang.
Ka mor'a ho paka tlhahlobo ke ea bohlokoa ho netefatsa botšepehi ba tiiso ea ho qetela ea hermetic, eo eleng ntlha e tloahelehileng haholo ya ho hloleha.
Mekhoa e kang ho kenella ka dae, ho senyeha ha vacuum, le ho lemoha ho dutla ha matla a phahameng (HVLD) li sebelisetsoa ho tiisa botšepehi ba tiiso.
Microscopic le electrochemical lihlahlobo tsa elektrochemi tsa ho bona le ho khetholla Menholes, e sitisang ka matla ts'ebetso ea ho thibelaAluminium Barrier Foil.
Qetello
Lipolelo tsa aluminium li emela maemo a khauta bakeng sa ho fihlela ts'ireletso e phahameng ea ho sisinyeha ha meroho. Moralo oa bona oa Morakha o tiisa haufi le-Zero Tomoso ho oksijene le mongobo, sireletsa botsitso ba apis e ntle. Ts'ebetso e akaretsang ea tšitiso e itšetleha ka boleng baAluminium Barrier Foil thepa le ho nepahala ha ts'ebetso ea ho tiisa, ho hloka kalafo e tsoelang pele ho litekanyetso tsa boleng bo tiileng.